Amphetamine use disorders are very varied
. Some are manifested in the short term and others can have effects for life. They range from simple intoxication to permanent psychotic disorders.
Amphetamine was first synthesized by L. Eledano, in 1887 . However, it was not until 1920 that its stimulation effects on the central nervous system were studied in detail. Such a discovery is due to Gordon Alles.
During Prohibition in the United States, pharmaceutical laboratories brought amphetamine to market with the trade name Benzedrine. Then they circulated a more powerful one called Dexedrine. Only many years later they became controlled substances.
What are amphetamines?
Amphetamines are stimulant drugs that accelerate the functions of the brain and of the whole organism. They circulate in the market illegally in the form of pills, capsules, tablets or powder. They are usually taken orally.
Amphetamines have a structural chemical formula very similar to that of adrenaline. There are two basic amphetamines from which most of the amphetamines that are distributed in the market are derived. These are the original formulas: Benzedrine and Dexedrine.
The most commonly used amphetamine preparations are amphetamine, phentermine, chlorphentermine and methamphetamine. There have also emerged some compounds derived from the above that are marketed with many names.
Effects of amphetamine
Amphetamine use disorders derive from the mechanism of action of this drug. These are mainly: increase in dopamine release, inhibition of serotonin reuptake and increase in noradrenaline release. The main pharmacological effects of amphetamines are the following:
- At the peripheral level. Increased pressure and heart rate. Contraction of the iris and intraocular pressure. Decrease in body secretions and contraction of the bladder sphincter, which makes urination difficult.
- Central nervous system . Increased alertness, greater intellectual and manual performance; decreased feeling of tiredness, sleepiness and hunger.
Recent research has shown that the use of amphetamines during adolescence causes permanent brain damage. It basically alters brain areas related to memory and learning ability.
Dependence and disorders due to consumption of amphetamine
The habitual consumption of amphetamine gives rise to a phenomenon of tolerance
. That is, every time you need to consume more of the drug to achieve the same effects. This progressively leads to dependence on this drug.
The main problem with amphetamine use is intoxication by this substance. In this case the typical symptoms are presented, which are: tachycardia, dilation of the pupil, sweating, nausea, vomiting, agitation or psychomotor retardation, confusion, etc.
Another of the disorders for amphetamine use is the abstention syndrome that occurs when the ingestion of this drug is interrupted. Symptoms include:
- Dysphoric mood.
- Recurring nightmares
- Hypersomnia or insomnia.
- Fatigue.
- Remarkable increase of appetite.
- Agitation or psychomotor retardation.
Other disorders due to amphetamine use
The habitual and prolonged ingestion causes disorders for consumption of amphetamine of greater severity. The main ones are:
- Delirium due to amphetamine poisoning.
- Psychotic disorder induced by amphetamine.
- Amphetamine-induced anxiety disorder.
- Amphetamine-induced sleep disorder.
- Sexual disorder caused by amphetamine.
- Mood disorder induced by amphetamine.
